Glimepiride + Pioglitazone + Metformin HCL Tablets

Description

Glimepiride + Pioglitazone + Metformin HCL Tablets are available with the branding “SPARMET PG-1” and are a group of drugs known as anti-diabetic drugs that help in the treatment of type 2 diabetes, particularly those patients whose blood sugar cannot be managed with diet and exercise. Type 2 diabetes is a long-term disorder that influences how our body handles glucose. Type 2 diabetic individuals produce little or no insulin, or the insulin they produce can't have its effect on the body (insulin resistance).

Glimepiride + Pioglitazone + Metformin HCL Tablets is a fixed-dose combination of three antidiabetic medicines, i.e., Glimepiride, Metformin, and Pioglitazone. Glimepiride stimulates the beta cells of the pancreas that secrete insulin. Therefore, insulin facilitates the elimination of sugar from the blood. Metformin prevents cells in the liver from producing sugar and slows down the absorption of sugar from the intestines. In addition, it makes muscle cells more sensitive to insulin which allows such cells to absorb sugar from the blood more efficiently. Pioglitazone makes liver, muscle, and fat cells more sensitive to insulin and allows cells to absorb glucose from the blood more efficiently. Thus, it controls blood sugar levels.

Medical Benefits

• This composition has three antidiabetic medications (Glimepiride, Metformin and Voglibose) useful in type 2 diabetes treatment.
• Glimepiride activates cells in the pancreas that secrete insulin that assists in sugar elimination from the blood.
• Metformin slows down the sugar release by cells in the liver and retards sugar absorption from the intestines.
• It also heightens the sensitivity of muscle cells to insulin so that these cells can effectively absorb sugar from the blood.
• Pioglitazone enhances the sensitivity of liver, muscle and adipose cells to insulin and facilitates cells to more effectively absorb glucose from blood.
• Moreover, it also reduces the liver's production of glucose and maintains the activity of beta cells in the pancreas that secretes insulin.

Directions For Use

• Take it daily at the same time, ideally in the evening after meals.
• Swallow the entire tablet with water.
• Do not stop taking Glimepiride + Pioglitazone + Metformin HCL Tablets without talking to your doctor, even if you feel better.

Storage

• Keep it away from children to avoid accidental ingestion.
• Store the tablet in a dry, cool place.
• Locate it away from direct sunlight or heat.

Precautions

• It can interact with other diabetes medications, water pills, thyroid medications, and anticonvulsants.
• Do not take alcohol as it might increase the risk of lactic acidosis.
• Tell your doctor if you have bladder cancer, unstable diabetes, lactic acidosis, diabetic ketoacidosis, or liver, kidney, heart, or eye diseases.
• Not to be taken during pregnancy; consult a doctor if pregnant or intending to become pregnant.
• Do not breastfeed as it can harm the baby; discuss with a doctor before use.
• Glimepiride + Pioglitazone + Metformin HCL Tablets can make you sleepy; drive only if you are alert.
• Use with caution if you have kidney or liver problems; the doctor may change the dose.

Side Effects

• Nausea
• Headache
• Metallic taste
• Diarrhoea
• Vomiting

Frequently Asked Questions (FAQs)

Can I use this drug with pregabalin?

Avoid it as it can cause weight gain and water retention, resulting in heart failure. Consult your doctor.

What is the difference between type 1 and type 2 diabetes?

Type 1 diabetes is when the body does not make insulin. Type 2 is when the body resists insulin.

May I discontinue this medication on my own?

No, do not discontinue suddenly. Your condition can become worse. Ask your doctor for alternatives.

Can this tablet lead to stomach discomfort?

Yes, it can. Take fluids in small quantities and chew food well.

Can I consume alcohol when taking this medicine?

No, alcohol increases the risk of lactic acidosis. Do not take alcohol.

What do I need to tell my doctor before I take this medicine?

Tell about any other medicines, medical conditions, pregnancy, or breastfeeding.